Toxicological Evaluation and Limit Values for Nonylphenol, Nonylphenol Ethoxylates, Tricresyl, Phosphates and Benzoic Acid

Preface

This series of reports constitutes a part of the work related to the setting of health based limit values for chemical substances in air, soil and drinking water.

In this report, the toxicological documentation for the setting of limit values for nonylphenol and nonylphenol ethoxylates, tricresylphosphates and benzoic acid are presented. For every substance, the following items are considered:,

part 1, physicochemical properties, production and uses, environmental occurrence and fate, and human exposure

part 2, toxicokinetic properties and toxicological mechanisms

part 3, human toxicity

part 4, animal toxicity

part 5, regulations and limit values in different media

part 6, summary of part 1 to 5

part 7, evaluation of toxicity and identification of critical effects

part 8, estimation of tolerable daily intake (TDI) and health based limit values

part 9, implementation of limit values to quality criteria

The work has been carried out by the Institute of Food Safety and Toxicology, Danish Veterinary and Food Administration as a contract work for the Danish Environmental Protection Agency. The work has been followed by a Steering Committee who has contributed to the work with professional expertise, proposals and criticism:

Linda Bagge, Chairman, Danish Environmental Protection Agency Poul Bo Larsen, Danish Environmental Protection Agency Erik Thomsen, Danish Environmental Protection Agency Hans Chr. Ellehauge, Danish Environmental Protection Agency Anders Carlsen, Medical Health Office for Viborg County Elle Laursen, National Board of Health Ole Ladefoged, Institute of Food Safety and Toxicology Elsa Nielsen, Institute of Food Safety and Toxicology