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Toxicological Evaluation and Limit Values for Nonylphenol, Nonylphenol Ethoxylates, Tricresyl, Phosphates and Benzoic Acid

10. References

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Appendix.

Summary of short and long term toxicity of o-TCP.

Route and duration Species Doses NOAEL Effects
Gavage, single dose Hens 300-700 mg/kg < 300 mg/kg OPIDN
Gavage, single dose Hens 58-580 mg/kg < 58 mg/kg OPIDN
Gavage, single dose Cats, dogs, cows, sheep, chicken   < 100 mg/kg OPIDN
Dermal, single dose Cats 100-2000 mg/kg 100 mg/kg OPIDN
Gavage, 90 days Hens 2.5-20 mg/kg 2.5 mg/kg OPIDN
Gavage,, 24 weeks, 5 day/week Rats 116 mg/kg <116 mg/kg heel walking
Gavage, 24 weeks, once every second week Rats 1160 mg/kg < 1160 mg/kg Severe hind limb effects
Gavage, 63 days Rats 10-100 mg/kg 10 mg/kg Acute cholinergic effects
Dermal, 90 days Cats 0.5-100 mg/kg 0.5 mg/kg leg weakness

Summary of short and long term toxicity data for TCP

Route and duration Species Dose range NOAEL Effects
Gavage, up to 14 doses 5 days/week Rats 360-5800 mg/kg 730 mg/kg Neurobehavioural, and body weight
Gavage, up to 14 doses 5 days/week Mice 360-5800 mg/kg < 360 mg/kg Hind limb grip strength reduced
Diet, 14 days Mice 0.437-7% 0.875% piloerection, tremors, diarrhoea
Gavage, 13 weeks Rats 50-800 mg/kg < 50 mg/kg Ovarian interstitial cell hypertrophy
Diet, 13 weeks Rats 900-13000 ppm < 900 ppm (65 mg/kg) Ovarian interstitial cell hypertrophy
Diet, 2 years Rats 75-300 ppm 150 ppm (7 mg/kg) Ovarian interstitial hyperplasia
Gavage, 13 weeks Mice 50-800 mg/kg < 50 mg/kg Ovarian interstitial cell hypertrophy
Diet, 13 weeks Mice 250-4200 ppm 1000 ppm (approximately 200 mg/kg) Reduced body weight
Diet, 2 years Mice 60-250 ppm 60 ppm (7 mg/kg) Liver (clear cell foci, fatty change)

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