Report on the Health Effects of Selected Pesticide Coformulants

Table 3: Summary table of critical effects and current regulation on selected coformulants (Tabel 3: Oversigtstabel over kritiske effekter og gældende regulering af udvalgte hjælpestoffer) Chemical name Acronym Critical effects EU- classificationa,1) OEL DK2) C-value3) Manganese (II) sulphate Manganese (II) sulphide Neurological effects: LOAEC humans 0.14-1.59 mg Mn/m3 as total dust Xn; R48/20/22 N; R51/53 - 0.2 mg Mn/m3 (inorganic compounds) 0.001 mg Mn/m3 (inorganic dust) Diammonium sulphate Lung: LOAEC rat 0.5-1 mg/m3 - - - Dimethyl ether DME Acute: CNS depression humans RDT: Liver NOEC rat 380 mg/m3 Fx; R12 1000 ppm (1885 mg/m3) 1 mg/m3 Hexamethylenetetramine Sensitisation inhalation, skin contact F; R11 R42/43 - - 1-Methyl-1,2-ethanediyl dioleate No data available - - - Isopropyl myristate Irritation skin, respiratory tract - - - Sodium ligninsulphonate Irritation eye, skin, respiratory tract - - - Calciumdodecylbenzene- sulphonate CaDBS Possibly irritation eye, skin, respiratory tract - by analogy with LAS - - - Ethylene glycol EG Kidney: NOAEL rat 200 mg/kg b.w./day Developmental effects: NOAEC mouse 1000 mg/m3 Irritation respiratory tract: LOAEC human 17 mg/m3 Xn; R22 10 ppm (26 mg/m3) - Propylene glycol PG Skin and mucous membrane irritation/dehydration - - - 2-Butoxyethanol EGBE Haemolysis: NOEC human above 3 mg/m3 Irritation eye, skin Irritation respiratory tract: NOAEC human above 100 mg/m3 Xn; R20/21/22 Xi; R36/38 20 ppm (98 mg/m3) 0.04 mg/m3 L 1-Methoxy-2-propanol 2PG1ME Irritation eye, mucous membranes, respiratory tract - 50 ppm (300 mg/m3) skin notation 1 mg/m3 Diethylene glycol mono-n-butyl ether DEGBE Irritation skin, eye RDT: skin irritation NOAEL 100-200 rat mg/kg b.w./day Xi; R36 100 mg/m3 0.02 mg/m3 L Dipropylene glycol monomethyl ether DPGME Eye and mucous membrane irritation - 50 ppm (300 mg/m3) skin notation 1 mg/m3 Polyethyleneglycol dodecylether polyEGDE Skin and eye irritation - - -
Chemical name Acronym Critical effects EU- classificationa,1) OEL DK2) C-value3) Cyclohexanone CNS depression: LOAEC human 162 mg/m3 Irritation skin, eye, respiratory tract R10 Xn; R20 10 ppm (40 mg/m3) skin notation 0.1 mg/m3 1-Methyl-2-pyrrolidone NMP Irritation eye, skin, respiratory tract Xi; R36/38 5 ppm (20 mg/m3) 0.5 mg/m3 4-Hydroxy-4-methyl-2 pentanone HMP Irritation eye, mucous membranes Xi, R36 50 ppm (240 mg/m3) 0.1 mg/m3