Human Bioaccessibility of Heavy Metals and PAH from Soil
Compound
Species
Toxicological response
Toxicological
parameter established
Toxicological basis
Bioavailability
incorporated
As
inorganic As-species
circulatory diseases, acute
toxicity
both chronic and acute
endpoints
25% of TDI2-value (chronic
toxicity) allocated to soil
exposure
NOAEL3 of 0,01 mg/kg for
acute exposure
the MCL is based on readily
absorbed As, i.e.: the water
soluble As content
Cd
inorganic Cd-species
adverse effects on kidneys,
nefrotoxicity
PTWI4
10% of PTWI results in MCL-
value of 5 mg/kg The MCL of
0,5 mg/kg is set to protect
from uptake in plants for
consumption
the MCL specifically addres-
ses bioavailability in plants
Cr
Cr(VI)
carcinogenic by inhalation,
sensitising, acute toxicity
no specific NOAEL/LOAEL5
overall assessment of data
no specific considerations
Cr
Cr(III + VI)
-
-
the MCL of 500 mg/kg set on
an administrative basis
no specific considerations
Cu
inorganic Cu-species
irritation of the gastro-
intestinal tract, adverse
effects on the liver
the provisional TDI of 0,5
mg/kg bw6/d7 for chronic
exposure also used for acute
exposure
the MCL is set to prevent
acute effects from soil
ingestion
the MCL is to protect against
water soluble Cu
Ni
inorganic Ni-species
increased reactivity in Ni-
allergic persons
LOAEL with respect to
worsening of allergic
reactions
human clinical study
a RAF8 of 30 is used
specifically for soil
Pb
inorganic Pb-species
neurotoxic response,
neurobehavioural
disturbances in children,
impaired IQ
NOAEL with respect to
increase in blood lead level
epidemiological/clinical
studies
the overall bioavailability for
lead from different sources is
considered
no specific factor is used for
lead in soil.
Zn
inorganic Zn-species
acute toxicity, irritation of
gastrointestinal tract
-
comparable dose tolerated
from drinkingwater
the MCL is based on water
soluble Zn.
PAH
total PAH9
benzo(a)pyrene
carcinogenic effects
cancer potency estimates
epidemiological data,
experimental animal data
the MCL set based on an
overall assessment for
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