Sequence Conditions Stomach, fasted state Stomach, fed conditions Small intestine, fasted state Small intestine, fed state L/S¹⁵ depends upon dose¹⁶ depends upon dose depends upon dose¹⁷ depends upon dose Solution hydrochloric acid, sodium chloride and sodium lauryl sulphate pH = 1,0 - 1,3 long life milch, 3,5% fat phosphate buffer pH = 6,5, lechitin, tauro- cholate, potassium chloride acetate buffer pH = 5,0, lechitin, tauro- cholate, potassium chloride Time 15 minutes 15 minutes 15 minutes 15 minutes First Temperature 37 °C¹⁸ 37 °C 37 °C 37 °C L/S - - - Solution - - - Time - - - Second Temperature - - -