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Effects of azole fungicides on the function of sex and thyroid hormones
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Intact animals |
Castrated control |
Control |
Flutamide |
Tebuconazole
50 mg/kg |
Tebuconazole 100 mg/kg |
Tebuconazole 150 mg/kg |
Propiconazole
50 mg/kg |
Propiconazole
100 mg/kg |
Propiconazole
150 mg/kg |
| Body weight (g) |
183±14 |
166±3 |
165±10 |
165±18 |
164±16 |
165±14 |
170±15 |
170±15 |
171±21 |
173±10 |
| Prostate (mg) |
87.5±10.8* |
5.7±3.6* |
49.2±18.0 |
11.1±5.9* a |
57.2±13.6 |
51.4±10.8 |
61.0±8.8 a |
53.8±15.2 |
43.0±13.7 |
59.2±12.9 |
| Seminal vesicles (mg) |
114.0±36.7 |
12.5±3.0* |
95.9±39.7 |
20.1±3.9* |
106.2±12.4 |
90.5±7.7 |
101.4±11.1 |
92.4±13.3 |
96.5±20.1 |
88.5±22.4 |
| LABC (mg) |
229±24 |
93±11* |
199±12 |
124±24* |
202±38 |
216.7±22.6 |
222±27 |
208.9±25 |
204±38 |
221±23 |
| Bulbourethral gl. (mg) |
15.8±4.1* |
1.7±0.7* a |
9.0±2.2 |
1.8±0.8* |
10.5±1.3 |
10.4±1.3 |
10.7±2.0 |
10.2±1.7 |
9.2±1.9 a |
10.9±1.5 |
| Pituitary (mg) |
6.2±0.5 |
7.6±1.0 |
6.4±0.6 |
6.6±1.9 |
6.5±0.7 |
6.7±0.9 |
7.5±1.0 |
6.9±0.6 |
7.4±0.7 |
7.5±0.7 |
| Thyroid (mg) |
9.5±3.8 |
9.1±5.0 |
8.0±2.0 |
8.3±1.1 |
8.0±1.0 |
8.2±1.8 |
8.4±3.0 |
8.1±1.8 |
7.7±2.7 |
7.3±1.4 |
| Liver (g) |
8.2±0.6* |
7.2±0.3 |
6.9±0.5 |
7.7±0.9 |
7.2±0.8 |
7.4±0.7 |
8.5±1.0* |
7.9±0.9 |
8.2±1.1* |
8.5±0.5* |
| Kidney (g) |
1.5±0.1 a |
1.3±0.1 |
1.3±0.1 |
1.3±0.1 |
1.2±0.1 |
1.3±0.1 |
1.4±0.2 |
1.4±0.1 |
1.4±0.2 |
1.4±0.1 |
All animals were castrated except for the intact control. All animals received testosterone propionate, except the intact and castrated controls, which only were given vehicle. The group named “Control” is the group used as control in the statistical analysis. Data represent mean±SEM; N=6 ; a: N= 5. * indicate statistically significant compared to controls by Dunnett’s test (P<0.05).
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Version 1.0 October 2007, © Danish Environmental Protection Agency
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