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Effects of azole fungicides on the function of sex and thyroid hormones
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Intact animals |
Castrated control |
Control |
Flutamide |
Tebuconazole
50 mg/kg |
Tebuconazole
100 mg/kg |
Tebuconazole
150 mg/kg |
Propiconazole
50 mg/kg |
Propiconazole
100 mg/kg |
Propiconazole
150 mg/kg |
| LH (ng/ml) |
1.20±0.54 |
22.02±18.92* |
0.82±1.34 |
15.79±6.17* |
0.86±0.77 |
0.50±0.62 |
1.02±0.95 |
1.63±1.23 |
1.49±2.77 |
1.86±1.91 |
| FSH (ng/ml) |
9.80±0.97* |
32.2±5.58* |
20.81±3.21 |
36.85±4.96* |
24.23±3.70 |
19.74±5.75 |
21.60±3.54 |
21.51±7.83 |
24.07±6.90 |
32.71±10.8* |
| T4 (nM) |
127±41 |
110±28 |
140±41 |
123±23 |
145±33 |
141±39 |
146±42 |
122±29 |
116±29 |
127±29 |
All animals, except the intact and castrated controls, received testosterone propionate. The group named “Control” is the group used as control in the statistical analysis.
Data represent mean±SEM; N=6.
* indicate statistically significant compared to controls by Dunnett’s test (P<0.05).
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Version 1.0 October 2007, © Danish Environmental Protection Agency
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