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Effects of azole fungicides on the function of sex and thyroid hormones
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Intact animals |
Castrated control |
Control |
Flutamide |
Tebuconazole
50 mg/kg |
Tebuconazole
100 mg/kg |
Tebuconazole
150 mg/kg |
Propiconazole
50 mg/kg |
Propiconazole
100 mg/kg |
Propiconazole
150 mg/kg |
| PBP C3/ 18S |
61.8±4.5 |
1.04±0.81* |
51.7±4.66 |
6.07±1.85* |
41.1±1.95 |
42.0±6.16 |
38.2±2.49 |
36.5±5.20 |
30.6±1.04 |
32.8±2.33 |
| ODC/ 18S (x 10-3) |
13.3±1.02* |
4.42±1.38* |
24.7±1.91 |
9.03±1.78* |
24.0±1.53 |
22.8±1.84 |
17.8±0.44* |
18.2±1.51* |
16.6±1.30* |
18.8±1.49* |
| TRPM-2/ 18S (x 10-2) |
1.62±0.48 |
25.5±10.2* |
0.93±0.08 |
7.56±4.13* |
1.02±0.10 |
1.05±0.16 |
1.07±0.09 |
0.94±0.09 |
1.06±0.12 |
1.05±0.07 |
| Compl.C3/ 18S (x 10-4) |
4.02±1.43 |
19.5±9.29* |
3.72±0.52 |
35.5±18.3* |
5.71±1.62 |
4.97±0.85 |
6.87±2.59 |
5.40±1.52 |
5.23±2.61 |
2.40±0.19 |
All animals, except the intact and castrated controls, received testosterone propionate. The group named “Control” is the group used as control in the statistical analysis.
Data represent the mean±SEM; N=6.
* indicate statistically significant compared to controls by Dunnett’s test (P<0.05).
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Version 1.0 October 2007, © Danish Environmental Protection Agency
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