Colophon

Development of an analysis method for quantification of colophonium components in cosmetic products

Title:
Development of an analysis method for quantification of colophonium components in cosmetic products

Abstract:
Earlier published analytical methods for identification and quantification of the major colophonium components have been thoroughly scrutinized from different aspects e. g. possibility to be used outside very sophisticated analytical laboratories, robustness, and possibility to detect compounds without derivatisation. Based on this, it was concluded that a new method was needed for the purpose of the present study. We have thus developed a reversed phase HPLC method with UV detection using diod-array-detector. Pure non-oxidized resin acids and a stable major oxidation product as a marker for a possible autoxidation and the formation of allergenic oxidation products are used as reference substances. The analytical separation obtained is good and has never been obtained before using HPLC methods.

Abstract in Danish:
Tidligere publicerede analytiske metoder til identifikation og kvantificering af de primære kolofonium komponenter blev undersøgt ud fra forskellige aspekter med henblik på udvælgelse af en analysemetode. De vigtigste aspekter var, at metoden skal kunne bruges af mindre avancerede analyselaboratorier, være robust og detektering af komponenter skal ske uden derivatisering. På baggrund af litteraturstudiet blev det besluttet, at en ny metode var nødvendig til dette projekt. Vi har derfor udviklet en omvendt fase HPLC metode med UV detektion ved brug af diode-array-detektor (DAD). Som referencestoffer blev anvendt rene ikke-oxiderede harpikssyrer og et stabilt oxidationsprodukt (sidstnævnte som markør for en mulig autooxidation og dannelse af allergifremkaldende oxidationsprodukter). Den analytiske separation er god, hvilket ikke tidligere har været opnået med en HPLC metode for kolofonium.

Series title and no.:
Environmental Project No. 1272 2009

Publisher:
Danish Environmental Protection Agency

Performing organization(s):
Danmarks Miljøundersøgelser (DMU)
Göteborgs Universitet (GU)
Stockholms Universitet (SU)

Copyright:
Danish Environmental Protection Agency

Creators:
Ulrika Nilsson
Pia Lassen
Ann-Therese Karlberg

Contributor:
Schultz Grafisk (web)

Language:
eng

URL:
http://www.mst.dk/

ISBN nr. Electronic version:
978-87-7052-927-3

ISBN nr. Printed version:
978-87-7052-928-0

Version:
1.0

Version/edition:
2009-03-27

Data formats:
html, gif, pdf, css

Inventory:
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Publisher category:
statslig