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Evaluation of the health risk to animals playing with phthalate containing toys

Contents

Sammenfatning

1 Introduction

2 Animal exposure

• 2.1 The relevant exposure scenario
• 2.2 Occurrence of phthalates in toys
• 2.3 Migration of phthalates from toy
• 2.4 Duration of gastrointestinal passage in dogs
• 2.5 Body weights of dogs
• 2.6 Estimating the exposure
  • 2.6.1 Estimation A - based on measured migration rate
  • 2.6.2 Estimation B - based on 10% (w/w) migration of phthalate

3 Toxicity

• 3.1 Critical effects of DEHP
  • 3.1.1 Studies in dogs
• 3.2 Critical effects of DINP
  • 3.2.1 Studies in dogs
• 3.3 NOAEL or LOAEL of DEHP and DINP
• 3.4 Relevance of effects observed in rats for effects in dogs
  • 3.4.1 DEHP
  • 3.4.2 DINP

4 Risk Assessment

• 4.1 Uncertainty factors or establishing minimal MOS
• 4.2 MOS
• 4.3 Critical period of exposure
• 4.4 Exposure to animals from other sources
• 4.5 Uncertainty and limitations

5 Conclusion

6 References

Abbreviations

Appendix

• Appendix 1
• Appendix 2
• Appendix 3

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Version 1.0 August 2006, © Danish Environmental Protection Agency