Toxicological Evaluation and Limit Values for Nonylphenol, Nonylphenol Ethoxylates, Tricresyl, Phosphates and Benzoic Acid

8. TDI, health based limit values

8. TDI, health based limit values
8.1 TDI
8.2 Limit value in soil
8.3 Limit value in drinking water
8.4 Limit value in air

NP

= 0.005 mg/kg b.w./day

The safety factor SF_I is set to 10 assuming that humans are more sensitive than animals. The SF_II is set to 10 to protect the most sensitive individuals in the population. The SF_III is set to 30 since a LOAEL is used and because data for genotoxicity and carcinogenicity are lacking.

NPE

= 0.013 mg/kg b.w./day

The safety factor SF_I is set to 10 assuming that humans are more sensitive than animals. The SF_II is set to 10 to protect the most sensitive individuals in the population. The SF_III is set to 30 since a LOAEL is used and because data for genotoxicity and carcinogenicity are lacking.

Allocation

The sources of NP and NPE exposure for the general population are via consumer products and via the environment through food, drinking water, and air. The size of these exposures is unknown, although it is expected that exposure via air is negligible.

For the purpose of setting a limit value, only 10 % of the TDI is allocated to ingestion of soil and 10 % to drinking water.

NP

Based on the TDI of 0.005 mg/kg b.w. per day for NP, and assuming a daily ingestion of 0.2 g soil for a child weighing 10 kg (w_child), a limit value is calculated:

= 25 mg/kg soil

NPE

Based on the TDI of 0.013 mg/kg b.w. per day for NPE, and assuming a daily ingestion of 0.2 g soil for a child weighing 10 kg (w_child), a limit value is calculated:

= 65 mg/kg soil

NP and NPE

The existing limit value for phenols in drinking water of 0.5 mg/l offers adequate protection against adverse health effects induced by NP or NPE.

8.4 Limit value in air

NP

= 0.017 mg/m³

NPE

= 0.05 mg/m³