Lægemiddel eller restprodukt |
Terapeutisk brug |
Testorganisme |
Toksicitet |
Område / betingelser |
Reference |
Acetylsalisylsyre |
Smertestillende middel |
Daphnia magna
|
EC50= 327,94 mg/L |
24 timer akut test (immobilitet) |
/8/ |
LC50= 162 -740 mg/L |
24 timers akut test |
/8/ |
EC50= 61 - 68 mg/L |
21 dages reproduktions test |
/8/ |
Ceriodaphnia dubia |
LC50= 630 mg/L |
24 timers akut test |
/8/ |
Dressina polymorpha (fisk) |
LC50= 138 mg/L |
24 timer akut test |
/8/ |
Austropotamobius pallipes p (fisk) |
LC50= 350-390 mg/L |
96 timers akut test |
/8/ |
Gambusia affinis (fisk) |
LC50= 435-485 mg/L |
96 timers akut test |
/8/ |
Lepomis macrochirus (fisk) |
LC50= 951-2010 mg/L |
96 timer akut test |
/8/ |
Orconectes limosus (crayfish)
|
LC50= 574-640 mg/L |
96 timer akut test |
/8/ |
LC50= 296-450 mg/L |
720 timer akut test |
/8/ |
Pimephales promelas
|
LC50= 880 mg/L |
96 timer akut test |
/8/ |
NOEC = 500 mg/L |
168 timer test (mortalitet) |
/8/ |
NOEC = 250 -500 mg/L |
168 timers vækst test |
/8/ |
Chlorella vulgaris
(grønalge)
|
LOEC = 670 mg/L |
91,3-122 dages vækst hæmning |
/8/ |
NOEC = 600 mg/L |
91,3-122 dages vækst hæmning |
/8/ |
Clofibrat |
Lipidsænkende middel |
Alge
|
EC10 = 5.4 mg/l |
Vækst hæmning |
/9/ |
EC50 = 12 mg/l |
|
|
Daphnia magna
|
LC10 = 17,7 mg/l |
Akut test |
|
LC 50 = 28,2 mg/l |
|
|
NOEC = 0,01 mg/l |
Reproduktions test |
|
LC10 = 0,0084 mg/l |
|
|
LC 50 = 0,106 mg/l |
|
|
Digoxin |
Hjerteglucosid |
Daphnia magna
|
EC50 = 12,8 mmol/L |
Akut test (immobilitet) |
/8/ |
EC50 = 0,031 mM |
Akut test (immobilitet), test udført på
aktiv stof |
/8/ |
LC50= 246 mM |
Akut test (mortalitet) |
/8/ |
|
|
|
|
|
|
Diazepam |
Psykofarmaka |
Daphnia magna
|
LC50 = 13,9 mg/l |
|
/10/ |
LC50 = 4,3 mg/l |
|
/11/ |
EC50 = 49,5 m mol/L (hele produktet) |
24 timers akut test (immobilitet) |
|
EC50 = 15 m
mol/L (aktiv stof) |
24 timers akut test (immobilitet) |
|
EC50 = 0,015 mM |
24 timers akut test (immobilitet) på
aktiv stof |
|
LC50 = 32,3 m M |
24 timers akut test (mortalitet) |
|
Daphnia pulex |
EC50 = 0,042 nM |
24 timers akut test (immobilitet) |
|
Peromyscus maniculatus (mus) |
LD50 = 1070 mg/kg |
72 timers oral gavage test |
|
Diethylstibestrol |
Hormon |
Oedogonium cardiacum (Alge) |
LC50 > 10 mg/l |
Alge toksicitet test |
/4/ |
Daphnia magna |
LC50 = 4 mg/l |
|
|
Culex pipiens |
LC50 = 4 |
|
|
Physa sp. |
LC50 > 10 mg/l |
|
|
Gambusia affinis (Moskito fisk) |
LC50 > 1 mg/l |
|
|
Diethylstibestrol acetat |
Hormon |
Oedogonium cardiacum (Alge) |
LC50 > 10 mg/l |
alge toksicitet test |
/4/ |
Daphnia magna |
LC50 = 10 mg/l |
|
|
Culex pipiens |
LC50 = > 10 mg/l |
|
|
Physa sp. |
LC50 > 10 mg/l |
|
|
Gambusia affinis (Moskito fisk) |
LC50 > 10 mg/l |
|
|
Fluoxetine HCl |
|
Mikroorganismer |
MIC = 57 ppm |
|
/4/ |
Daphnia sp.
|
EC50 = 0,94 ppm |
|
/4/ |
NOEC = 0,09 ppm |
|
/4/ |
Grønalge
|
EC50 0,031 ppm |
|
/4/ |
NOEC = 0,01 ppm |
|
/4/ |
Hydrogen peroxid |
Middel mod sygdomme i
mundhule eller tænder |
Lepomis macrochirus (bluegill) |
LC50 = 21,4-26,7 ppm |
96 timers akut test |
/8/ |
Onchorhynchus mykiss (regnbueørred)
|
LC50 = 5,9-22 ppm |
96 timers akut test |
/8/ |
Trachurus japonicus (jack makrel) |
LC50 = 89 mg/L |
24 timers test |
/8/ |
Oscillatoria rubescens (blågrønalge) |
CLR = 0,350 mg/L |
29 timers klorofyl reduktions test |
/8/ |
Aphamizomenon flos-aquae (blågrønalge) |
EC50 = 0,9 mg/L |
22 timer nitrogen fikserings test |
/8/ |
Sciaenops ocellatus |
NOEC = 0,01% mættet opløsning |
Mortalitet efter 5 minutters ophold i
testopløsning |
/8/ |
Hospitalsspildevand indeholdende
Mitomycin C og/eller Cisplatin |
Kemoterapeutisk middel |
Umu C test (bakterie) |
Genotoksisk aktivitet |
Hospital spildevandsprøver |
/4/ |
Ibuprofen |
Smertestillende middel |
Trichphyton rubrum (dermatofyter) |
MIC = 5- 10 m
g/ml |
MIC = minimum hæmnings koncentration ved
pH = 5 |
/4/ |
Trichophyton mentagrophytes
(dermatofyter) |
MIC = 5 - 20 m
g/ml |
|
|
Trichophyton tonsurans
(dermatofyter) |
MIC = 20 -40 m
g/ml |
|
|
Microsporum fulva (dermatofyter) |
MIC = 10 - 40 m
g/ml |
|
|
Epidermophytes floccosum
(dermatofyter) |
MIC = 20 - 40 m
g/ml |
|
|
Cogida albicans (pathogenic gær) |
MIC = 140 - 160 m
g/ml |
|
|
Staphylococus aureus (bakterie) |
MIC = 40 - 80 m
g/ml |
|
|
Mucor sp. |
MIC = 120 - 140 m
g/ml |
|
|
Staphylococus aureus (bakterie)
|
MIC = 150 m
g/ml at pH = 7 |
|
/4/ |
MIC = 50 m
g/ml at pH = 6 |
|
|
Daphnia magna (water flea) |
EC50 (48 timer) = 9.06 to 11.5 mg/l. NOEC
ca. 3 mg/l |
Akut toksicitet |
/12/ |
Lepomis machrochirus (bluegill
sunfish)
|
LC50 (96 timer) = 173 mg/l |
Akut toksicitet |
|
NOEC 10 mg/l. |
|
|
Mysidopsis bahia
(mysid)
|
NEL (96 timer) > 100 mg/l |
Akut toksicitet |
|
NOEC = 30 mg/l |
|
|
Cyprinodon variegatus (sheepshead
minnow) |
NEL (96 timer) > 300 mg/l |
Akut toksicitet |
|
Selenastrum capricornutum
(ferskvandsgrønalge) |
NEL (96 timer) > 30 mg/l |
|
|
Skeletonema costatum (saltwater,
diatom) |
EC50 (96 timer) = 7.1 mg/l |
|
|
Microtoxâ
(bakterie) |
EC50 (5 mins) = 12.3 mg/l |
|
|
Kanamycin |
Antibiotikum |
Bakterie |
|
Antibiotikum resistens udviklet i
miljøprøver |
/4/ |
Metronidazol |
Antibiotikum |
Chlorella sp. (grøn alge) |
EC10 (72 timer) = 2.03 mg/l |
|
|
Selenastrum carpricronutum (ferskvandsgrønalge) |
EC10 (72 timer) = 19 mg/l |
|
/4/ |
Neomycin |
Antibiotikum |
Bakterie |
|
Antibiotikum resistens udviklet i
miljøprøver |
/4/ |
Nikotin |
|
Daphnia magna
|
LC50 = 3,7 mg/l |
|
/10/ |
LC50 = 5,7 mg/l |
|
/10/ |
Paracetamol |
Smertestillende middel |
Daphnia magna
|
EC50 = 0,90 mM = 136 mg/L |
24 timers akut test |
/8/ |
EC50= 9,2 mg/L |
48 timers akut test (ikke standard) |
/8/ |
Pimephales promelas (elritse) |
LC50 = 814 mg/L |
96 timers akut test (mortalitet) |
/8/ |
Streptocephalus proboscideu (fairy
shrimp) |
LC50 = 196 m
mol/L = 29,6 mg/L |
24 timers akut test (mortalitet) |
/8/ |
Propanolol HCl |
Betareceptor blokker |
Daphnia magna
|
LC50 = 17,7 mg/l |
|
/10/ |
LC50 = 3,1 mg/l |
|
/11/ |
Østrogen |
Hormon |
Lucerne planter
|
0,02-2nmol/l signifikant øget plante
vækst. |
Overrislingsvand |
/4/ |
200-2000nmol/l signifikant faldende
plante vækst. |
|
|
Daphnia magna |
LC50 = 1,09 mg/L |
48 timer akut test (ikke standard) |
/8/ |
Peromyscus maniculatus
(mus)
|
LD50 = 1070 mg/kg |
72 timers oral gavage test |
/8/ |
|
|
|
17a
-Ethinylestradiol |
Hormon |
Alge
|
EC10 = 0,054 mg/l |
|
/9/ |
EC50 = 0,84 mg/l |
|
|
Daphnia sp.
|
NOEC = 0,01 mg/l |
Reproduktion test |
|
EC10 = 0,0125 mg/l |
|
|
EC50 = 0,105 mg/l |
|
|
EC10 = 3,2 mg/l |
Akut test |
|
EC50 = 5,7 mg/l |
|
|