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Appendices 1-18 to: Report on the Health Effects of Selected Pesticide Coformulants

138     Human toxicity

138.1     Single and repeated dose toxicity

12 subjects of both sexes were exposed by inhalation to 100 ppm HMP (equivalent to 483 mg/m³) for 15 minutes. The majority of them found the odour and taste objectionable and complained about eye, nose and throat irritation although they indicated that they could work an 8 hour-day in 100 ppm. (Silverman et al. 1946).

Pulmonary discomfort and eye, nose and throat irritation at 400 ppm (equivalent to 1932 mg/m³) was reported (unpublished data by Shell - quoted from Patty’s 1982).

 HMP is reported to be defatting to the skin following repeated exposure (Patty’s 1982).

A man who had painted a floor over three days with a paint containing HMP and ethanol as solvents was diagnosed to have glomerulonephritis about 40 days after the exposure. The man recovered within a year after immunosuppressive therapy. (von Scheele et al. 1976 – quoted from A&H 1989 and DPIMR 1996).

138.2     Toxicity to reproduction

No information was found.

138.3     Mutagenic and genotoxic effects

No information was found.

138.4     Carcinogenic effects

No information was found.

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