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Appendices 1-18 to: Report on the Health Effects of Selected Pesticide Coformulants
Table of Contents
Appendix 1: Manganese (II) sulphate, Manganese (II) sulphide
1 General description
1.1 Identity
1.2 Physical / chemical properties
2 Toxicokinetics
2.1 Absorption
2.1.1 Inhalation
2.1.2 Oral intake
2.1.3 Dermal contact
2.2 Distribution
2.2.1 Inhalation
2.2.2 Oral intake
2.2.3 Dermal contact
2.2.4 Other routes
2.3 Elimination
2.3.1 Inhalation
2.3.2 Oral intake
2.3.3 Dermal contact
2.3.4 Other routes
2.4 Mode of action
3 Human toxicity
3.1 Single dose toxicity
3.2 Repeated dose toxicity
3.2.1 Inhalation
3.2.2 Oral intake
3.2.3 Dermal contact
3.3 Toxicity to reproduction
3.3.1 Inhalation
3.3.2 Oral intake
3.3.3 Dermal contact
3.4 Mutagenic and genotoxic effects
3.5 Carcinogenic effects
4 Animal toxicity
4.1 Single dose toxicity
4.2 Repeated dose toxicity
4.2.1 Inhalation
4.2.2 Oral intake
4.2.3 Dermal contact
4.2.4 Other routes
4.3 Toxicity to reproduction
4.3.1 Inhalation
4.3.2 Oral intake
4.3.3 Dermal contact
4.3.4 Parenteral administration
4.4 Mutagenic and genotoxic effects
4.4.1 In vitro studies
4.4.2 In vivo studies
4.5 Carcinogenic effects
5 Regulations
5.1 Ambient air
5.2 Drinking water
5.3 Soil
5.4 Occupational Exposure Limits
5.5 Classification
5.6 IARC
5.7 US-EPA
5.8 ATSDR
6 Summary 6.1 Description
6.2 Toxicokinetics
6.3 Human toxicity
6.3.1 Single dose toxicity
6.3.2 Repeated dose toxicity
6.3.3 Toxicity to reproduction
6.3.4 Mutagenic and genotoxic effects
6.3.5 Carcinogenic effects
6.4 Animal toxicity
6.4.1 Single dose toxicity
6.4.2 Repeated dose toxicity
6.4.3 Toxicity to reproduction
6.4.4 Mutagenic and genotoxic effects
6.4.5 Carcinogenic effects
7 References
Appendix 2: Diammonium sulphate
8 General description
8.1 Identity
8.2 Physical / chemical properties
9 Toxicokinetics
9.1 Absorption, distribution, and elimination
9.1.1 Inhalation
9.1.2 Oral intake
9.1.3 Dermal contact
9.1.4 Other routes
9.2 Mode of action
10 Human toxicity
10.1 Single dose toxicity
10.1.1 Inhalation
10.1.2 Oral intake
10.1.3 Dermal contact
10.1.4 Other routes
10.2 Repeated dose toxicity
10.3 Toxicity to reproduction
10.4 Mutagenic and genotoxic effects
10.5 Carcinogenic effects
11 Animal toxicity
11.1 Single dose toxicity
11.1.1 Inhalation
11.1.2 Oral intake
11.1.3 Dermal contact
11.1.4 Other routes
11.2 Repeated dose toxicity
11.2.1 Inhalation
11.2.2 Oral intake
11.2.3 Dermal contact
11.2.4 Other routes
11.3 Toxicity to reproduction
11.4 Mutagenic and genotoxic effects
11.4.1 In vitro studies
11.4.2 In vivo studies
11.5 Carcinogenic effects
12 Regulations
12.1 Ambient air
12.2 Drinking water
12.3 Soil
12.4 Occupational Exposure Limits
12.5 Classification
12.6 IARC
12.7 US-EPA
13 Summary
13.1 Description
13.2 Toxicokinetics
13.3 Human toxicity
13.3.1 Single dose toxicity
13.3.2 Repeated dose toxicity
13.3.3 Toxicity to reproduction
13.3.4 Mutagenic and genotoxic effects
13.3.5 Carcinogenic effects
13.4 Animal toxicity
13.4.1 Single dose toxicity
13.4.2 Repeated dose toxicity
13.4.3 Toxicity to reproduction
13.4.4 Mutagenic and genotoxic effects
13.4.5 Carcinogenic effects
14 Evaluation
15 References
Appendix 3: Dimethyl ether (DME)
16 General description
16.1 Identity
16.2 Physical / chemical properties
17 Toxicokinetics
17.1 Mode of action
18 Human toxicity
18.1 Single dose toxicity
18.1.1 Inhalation
18.1.2 Oral intake
18.1.3 Dermal contact
18.2 Repeated dose toxicity
18.3 Toxicity to reproduction
18.4 Mutagenic and genotoxic effects
18.5 Carcinogenic effects
19 Animal toxicity
19.1 Single dose toxicity
19.1.1 Inhalation
19.1.2 Oral intake
19.1.3 Dermal contact
19.1.4 Other routes
19.2 Repeated dose toxicity
19.2.1 Inhalation
19.2.2 Other routes
19.3 Toxicity to reproduction
19.3.1 Inhalation
19.3.2 Other routes
19.4 Mutagenic and genotoxic effects
19.4.1 In vitro studies
19.4.2 In vivo studies
19.5 Carcinogenic effects
20 Regulations
20.1 Ambient air
20.2 Drinking water
20.3 Soil
20.4 Occupational Exposure Limits
20.5 Classification
20.6 IARC
20.7 US-EPA
21 Summary
21.1 Description
21.2 Toxicokinetics
21.3 Human toxicity
21.4 Animal toxicity
21.4.1 Single dose toxicity
21.4.2 Repeated dose toxicity
21.4.3 Toxicity to reproduction
21.4.4 Mutagenic and genotoxic effects
21.4.5 Carcinogenic effects
22 Evaluation
23 References
Appendix 4: Hexamethylenetetramine
24 General description
24.1 Identity
24.2 Physical / chemical properties
25 Toxicokinetics
25.1 Absorption
25.2 Distribution
25.3 Elimination
25.4 Mode of action
26 Human toxicity
26.1 Single dose toxicity
26.2 Repeated dose toxicity
26.2.1 Inhalation
26.2.2 Oral intake
26.2.3 Dermal contact
26.2.4 Other routes
26.3 Toxicity to reproduction
26.4 Mutagenic and genotoxic effects
26.5 Carcinogenic effects
27 Animal toxicity
27.1 Single dose toxicity
27.1.1 Inhalation
27.1.2 Oral intake
27.1.3 Dermal contact
27.1.4 Other routes
27.2 Repeated dose toxicity
27.2.1 Inhalation
27.2.2 Oral intake
27.2.3 Dermal contact
27.2.4 Other routes
27.3 Toxicity to reproduction
27.3.1 Inhalation
27.3.2 Oral intake
27.3.3 Dermal contact
27.3.4 Other routes
27.4 Mutagenic and genotoxic effects
27.4.1 In vitro studies
27.4.2 In vivo studies
27.5 Carcinogenic effects
27.5.1 Inhalation
27.5.2 Oral intake
27.5.3 Dermal contact
27.5.4 Other routes
28 Regulations
28.1 Ambient air
28.2 Drinking water
28.3 Food
28.4 Cosmetics
28.5 Drugs
28.6 Soil
28.7 Occupational Exposure Limits
28.8 Classification
28.9 IARC
28.10 US-EPA
29 Summary
29.1 Description
29.2 Toxicokinetics
29.3 Human toxicity
29.3.1 Single dose toxicity
29.3.2 Repeated dose toxicity
29.3.3 Toxicity to reproduction
29.3.4 Mutagenic and genotoxic effects
29.3.5 Carcinogenic effects
29.4 Animal toxicity
29.4.1 Single dose toxicity
29.4.2 Repeated dose toxicity
29.4.3 Toxicity to reproduction
29.4.4 Mutagenic and genotoxic effects
29.4.5 Carcinogenic effects
30 Evaluation
31 References
Appendix 5: 1-Methyl-1,2-ethanediyl dioleate
32 General description
32.1 Identity
32.2 Physical / chemical properties
33 Toxicokinetics
34 Human toxicity
35 Animal toxicity
36 Regulations
37 Summary
38 Evaluation
39 References
Appendix 6: Isopropyl myristate
40 General description
40.1 Identity
40.2 Physical / chemical properties
41 Toxicokinetics
41.1 Absorption, distribution and elimination
41.2 Mode of action
41.3 Influence on skin permeability of other chemicals
42 Human toxicity
42.1 Single dose toxicity
42.1.1 Inhalation
42.1.2 Oral intake
42.1.3 Dermal contact
42.1.4 Other routes
42.2 Repeated dose toxicity
42.2.1 Inhalation
42.2.2 Oral intake
42.2.3 Dermal contact
42.2.4 Other routes
42.3 Toxicity to reproduction
42.4 Mutagenic and genotoxic effects
42.5 Carcinogenic effects
43 Animal toxicity
43.1 Single dose toxicity
43.1.1 Inhalation
43.1.2 Oral intake
43.1.3 Dermal contact
43.1.4 Other routes
43.2 Repeated dose toxicity
43.2.1 Inhalation
43.2.2 Oral intake
43.2.3 Dermal contact
43.2.4 Other routes
43.3 Toxicity to reproduction
43.4 Mutagenic and genotoxic effects
43.5 Carcinogenic effects
44 Regulations
44.1 Ambient air
44.2 Drinking water
44.3 Food
44.4 Cosmetics
44.5 Soil
44.6 Occupational Exposure Limits
44.7 Classification
44.8 IARC
44.9 US-EPA
45 Summary
45.1 Description
45.2 Toxicokinetics
45.3 Human toxicity
45.4 Animal toxicity
45.4.1 Single dose toxicity
45.4.2 Repeated dose toxicity
45.4.3 Toxicity to reproduction
45.4.4 Mutagenic and genotoxic effects
45.4.5 Carcinogenic effects
46 Evaluation
47 References
Appendix 7: Sodium ligninsulphonate
48 General description
48.1 Identity
48.2 Physical / chemical properties
49 Toxicokinetics
50 Human toxicity
51 Animal toxicity
51.1 Single dose toxicity
51.1.1 Inhalation
51.1.2 Oral intake
51.1.3 Dermal contact
51.1.4 Other routes
51.2 Repeated dose toxicity
51.2.1 Inhalation
51.2.2 Oral intake
51.2.3 Dermal contact
51.2.4 Other routes
51.3 Toxicity to reproduction
51.4 Mutagenic and genotoxic effects
51.5 Carcinogenic effects
52 Regulations
53 Summary
53.1 Description
53.2 Toxicokinetics
53.3 Human toxicity
53.4 Animal toxicity
53.4.1 Single dose toxicity
53.4.2 Repeated dose toxicity
53.4.3 Toxicity to reproduction
53.4.4 Mutagenic and genotoxic effects
53.4.5 Carcinogenic effects
54 Evaluation
55 References
Appendix 8: Calciumdodecylbenzenesulphonate (CaDBS)
56 General description
56.1 Identity
56.2 Physical / chemical properties
57 Toxicokinetics
2.1 Absorption, distribution, metabolism and elimination
57.1 Mode of action
58 Human toxicity
59 Animal toxicity
59.1 Single dose toxicity
59.1.1 Oral intake
60 Regulations
60.1 Ambient air
60.2 Drinking water
60.3 Soil
60.4 Occupational Exposure Limits
60.5 EU Classification
60.6 IARC
60.7 US-EPA
61 Summary
61.1 Description
61.2 Toxicokinetics
61.3 Human toxicity
61.4 Animal toxicity
62 Evaluation
63 References
Appendix 9: Ethylene glycol (EG)
64 General description
64.1 Identity
64.2 Physical / chemical properties
65 Toxicokinetics
65.1 Absorption, distribution, and excretion
65.1.1 Inhalation
65.1.2 Oral intake
65.1.3 Dermal contact
65.2 Metabolism
65.3 Mode of action
66 Human toxicity
66.1 Single and repeated dose toxicity
66.1.1 Inhalation
66.1.2 Oral intake
66.1.3 Dermal contact
66.1.4 Skin irritation
66.1.5 Eye irritation
66.1.6 Skin sensitisation
66.2 Toxicity to reproduction
66.3 Mutagenic and genotoxic effects
66.4 Carcinogenic effects
67 Animal toxicity
67.1 Single dose toxicity
67.1.1 Inhalation
67.1.2 Oral intake
67.1.3 Dermal contact
67.1.4 Skin irritation
67.1.5 Eye irritation
67.1.6 Sensitisation
67.2 Repeated dose toxicity
67.2.1 Inhalation
67.2.2 Oral intake
67.2.3 Dermal contact
67.3 Toxicity to reproduction
67.3.1 Inhalation
67.3.2 Oral intake
67.3.3 Dermal contact
67.4 Mutagenic and genotoxic effects
67.4.1 In vitro studies
67.4.2 In vivo studies
67.5 Carcinogenic effects
68 Regulations
68.1 Ambient air
68.2 Drinking water
68.3 Soil
68.4 Occupational Exposure Limits
68.5 Classification
68.6 IARC
68.7 US-EPA
69 Summary
69.1 Description
69.2 Toxicokinetics
69.3 Human toxicity
69.4 Animal toxicity
69.4.1 Single dose toxicity
69.4.2 Repeated dose toxicity
69.4.3 Toxicity to reproduction
69.4.4 Mutagenic and genotoxic effects
69.4.5 Carcinogenic effects
70 Evaluation
71 References
Appendix 10: Propylene glycol (PG)
72 General description
72.1 Identity
72.2 Physico / chemical properties
73 Toxicokinetics
73.1 Inhalation
73.2 Oral intake
73.3 Dermal contact
73.4 Mode of action
74 Human toxicity
74.1 Single dose toxicity
74.1.1 Inhalation
74.1.2 Oral intake
74.1.3 Dermal contact
74.1.4 Irritation and sensitisation
74.2 Repeated dose toxicity
74.2.1 Inhalation
74.2.2 Oral intake
74.2.3 Dermal contact
74.3 Toxicity to reproduction
74.4 Mutagenic and genotoxic effects
74.5 Carcinogenic effects
75 Animal toxicity
75.1 Single dose toxicity
75.1.1 Inhalation
75.1.2 Oral intake
75.1.3 Dermal contact
75.1.4 Irritation and sensitisation
75.2 Repeated dose toxicity
75.2.1 Inhalation
75.2.2 Oral intake
75.2.3 Dermal contact
75.3 Toxicity to reproduction
75.3.1 Inhalation
75.3.2 Oral intake
75.3.3 Dermal exposure
75.4 Mutagenic and genotoxic effects
75.4.1 In vitro studies
75.4.2 In vivo studies
75.5 Carcinogenic effects
75.5.1 Inhalation
75.5.2 Oral intake
75.5.3 Dermal contact
76 Regulations
76.1 Ambient air
76.2 Drinking water
76.3 Soil
76.4 Occupational Exposure Limits
76.5 ADI
76.6 EU-Classification
76.7 IARC
76.8 US-EPA
77 Summary
77.1 Description
77.2 Toxicokinetics
77.3 Human toxicity
77.3.1 Single dose toxicity
77.3.2 Irritation and sensitisation
77.3.3 Repeated dose toxicity
77.4 Animal toxicity
77.4.1 Single dose toxicity
77.4.2 Irritation and Sensitisation
77.4.3 Repeated dose toxicity
77.4.4 Toxicity to reproduction
77.4.5 Mutagenic and genotoxic effects
77.4.6 Carcinogenic effects
78 Evaluation
79 References
Appendix 11: 2-Butoxyethanol (EGBE)
80 General description
80.1 Identity
80.2 Physical / chemical properties
81 Toxicokinetics
81.1 Absorption, distribution, excretion
81.1.1 Inhalation
81.1.2 Oral intake
81.1.3 Dermal contact
81.2 Elimination
81.3 Mode of action
82 Human toxicity
82.1 Single dose toxicity
82.1.1 Inhalation
82.1.2 Oral intake
82.1.3 Dermal contact
82.1.4 In vitro studies
82.2 Irritation
82.3 Sensitisation
82.4 Repeated dose toxicity
82.5 Toxicity to reproduction
82.6 Mutagenic and genotoxic effects
82.7 Carcinogenic effects
83 Animal toxicity
83.1 Single dose toxicity
83.1.1 Inhalation
83.1.2 Oral intake
83.1.3 Dermal contact
83.1.4 In vitro studies
83.2 Irritation
83.2.1 Skin irritation
83.2.2 Eye irritation
83.2.3 Respiratory tract irritation
83.3 Sensitisation
83.4 Repeated dose toxicity
83.4.1 Inhalation
83.4.2 Oral intake
83.4.3 Dermal contact
83.5 Toxicity to reproduction
83.5.1 Inhalation
83.5.2 Oral intake
83.5.3 Dermal contact
83.6 Mutagenic and genotoxic effects
83.6.1 In vitro studies
83.6.2 In vivo studies
83.7 Carcinogenic effects
84 Regulations
84.1 Ambient air
84.2 Drinking water
84.3 Soil
84.4 Occupational Exposure Limits
84.5 EU Classification
84.6 IARC
84.7 US-EPA
85 Summary
85.1 Description
85.2 Toxicokinetics
85.3 Human toxicity
85.3.1 Single dose toxicity, irritation
85.3.2 Irritation, sensitisation
85.3.3 Repeated dose toxicity
85.3.4 Toxicity to reproduction
85.3.5 Mutagenic and genotoxic effects
85.3.6 Carcinogenic effects
85.4 Animal toxicity
85.4.1 Single dose toxicity
85.4.2 Irritation
85.4.3 Sensitisation
85.4.4 Repeated dose toxicity
85.4.5 Toxicity to reproduction
85.4.6 Mutagenic and genotoxic effects
85.4.7 Carcinogenic effects
86 Evaluation
87 References
Appendix 12: 1-Methoxy-2-propanol (2PG1ME)
88 General description
88.1 Identity
88.2 Physical / chemical properties
89 Toxicokinetics
89.1 Absorption
89.2 Distribution
89.3 Metabolism and elimination
89.4 Mode of action
90 Human toxicity
90.1 Single dose toxicity
90.1.1 Inhalation
90.1.2 Oral intake
90.1.3 Dermal contact
90.1.4 Irritation
90.2 Repeated dose toxicity
90.3 Toxicity to reproduction
90.4 Mutagenic and genotoxic effects
90.5 Carcinogenic effects
91 Animal toxicity
91.1 Single dose toxicity
91.1.1 Inhalation
91.1.2 Oral intake
91.1.3 Dermal contact
91.1.4 Irritation
91.1.5 Sensitisation
91.2 Repeated dose toxicity
91.2.1 Inhalation
91.2.2 Oral intake
91.2.3 Dermal contact
91.3 Toxicity to reproduction
91.3.1 Inhalation
91.3.2 Oral intake
91.3.3 Dermal contact
91.4 Mutagenic and genotoxic effects
91.4.1 In vitro studies
91.4.2 In vivo studies
91.5 Carcinogenic effects
91.5.1 Inhalation
92 Regulations
92.1 Ambient air
92.2 Drinking water
92.3 Soil
92.4 Occupational Exposure Limits
92.5 Classification
92.6 IARC
92.7 US-EPA
93 Summary
93.1 Description
93.2 Toxicokinetics
93.3 Human toxicity
93.3.1 Single dose toxicity
93.4 Animal toxicity
93.4.1 Single dose toxicity
93.4.2 Repeated dose toxicity
93.4.3 Toxicity to reproduction
93.4.4 Mutagenic and genotoxic effects
93.4.5 Carcinogenic effects
94 Evaluation
95 References
Appendix 13: Diethylene glycol mono-n-butyl ether (DEGBE)
96 General description
96.1 Identity
96.2 Physical / chemical properties
97 Toxicokinetics
97.1 Absorption, distribution and excretion
97.2 Mode of action
98 Human toxicity
98.1 Single and repeated dose toxicity
98.2 Irritation and sensitisation
98.3 Toxicity to reproduction
98.4 Mutagenic and genotoxic effects
98.5 Carcinogenic effects
99 Animal toxicity
99.1 Single dose toxicity
99.1.1 Inhalation
99.1.2 Oral intake
99.1.3 Dermal contact
99.1.4 Skin irritation
99.1.5 Eye irritation
99.1.6 Sensitisation
99.2 Repeated dose toxicity
99.2.1 Inhalation
99.2.2 Oral intake
99.2.3 Dermal contact
99.3 Toxicity to reproduction
99.3.1 Inhalation
99.3.2 Oral intake
99.3.3 Dermal contact
99.4 Mutagenic and genotoxic effects
99.4.1 In vitro studies
99.4.2 In vivo studies
99.5 Carcinogenic effects
100 Regulations
100.1 Ambient air
100.2 Drinking water
100.3 Soil
100.4 Occupational Exposure Limits
100.5 Classification
100.6 IARC
100.7 US-EPA
101 Summary
101.1 Description
101.2 Toxicokinetics
101.3 Human toxicity
101.4 Animal toxicity
101.4.1 Single dose toxicity
101.4.2 Repeated dose toxicity
101.4.3 Toxicity to reproduction
101.4.4 Mutagenic and genotoxic effects
101.4.5 Carcinogenic effects
102 Evaluation
103 References
Appendix 14: Dipropylene glycol monomethyl ether (DPGME)
104 General description
104.1 Identity
104.2 Physical / chemical properties
105 Toxicokinetics
105.1 Mode of action
106 Human toxicity
106.1 Single dose toxicity
3.1.1 Inhalation
3.1.2 Eye irritation
106.2 Repeated dose toxicity
106.2.1 Inhalation and dermal contact
106.2.2 Oral intake
106.2.3 Skin irritation and sensitisation
106.3 Toxicity to reproduction
106.4 Mutagenic and genotoxic effects
106.5 Carcinogenic effects
107 Animal toxicity
107.1 Single dose toxicity
107.1.1 Inhalation
107.1.2 Oral intake
107.1.3 Dermal contact
4.1.5 Skin irritation
4.1.6 Eye irritation
107.1.4 Skin sensitisation
107.2 Repeated dose toxicity
107.2.1 Inhalation
107.2.2 Oral intake
107.2.3 Dermal contact
107.3 Toxicity to reproduction
107.3.1 Inhalation
107.3.2 Other routes
107.4 Mutagenic and genotoxic effects
107.4.1 In vitro studies
107.4.2 In vivo studies
107.5 Carcinogenic effects
108 Regulations
108.1 Ambient air
108.2 Drinking water
108.3 Soil
108.4 Occupational Exposure Limits
108.5 EU-Classification
108.6 IARC
108.7 US-EPA
109 Summary
109.1 Description
109.2 Toxicokinetics
109.3 Human toxicity
109.3.1 Single dose toxicity
109.3.2 Repeated dose toxicity
109.3.3 Toxicity to reproduction
109.3.4 Mutagenic and genotoxic effects
109.3.5 Carcinogenic effects
109.4 Animal toxicity
109.4.1 Single dose toxicity
109.4.2 Repeated dose toxicity
109.4.3 Toxicity to reproduction
109.4.4 Mutagenic and genotoxic effects
109.4.5 Carcinogenic effects
110 Evaluation
111 References
Appendix 15: Polyethylene glycol dodecylether (polyEGDE)
112 General description
112.1 Identity
112.2 Physico / chemical properties
113 Toxicokinetics
114 Human toxicity
115 Animal toxicity
115.1 Single dose toxicity
115.1.1 Inhalation
115.1.2 Oral intake
115.1.3 Dermal contact
115.1.4 Irritation
115.2 Repeated dose toxicity
115.3 Toxicity to reproduction
115.4 Mutagenic and genotoxic effects
115.4.1 In vitro studies
115.4.2 In vivo studies
115.5 Carcinogenic effects
116 Regulations
116.1 Ambient air
116.2 Drinking water
116.3 Soil
116.4 Occupational Exposure Limits
116.5 EU-Classification
116.6 IARC
116.7 US-EPA
117 Summary
117.1 Description
117.2 Toxicokinetics
117.3 Human toxicity
117.4 Animal toxicity
117.4.1 Single dose toxicity
117.4.2 Repeated dose toxicity
117.4.3 Toxicity to reproduction
117.4.4 Mutagenic and genotoxic effects
117.4.5 Carcinogenic effects
118 Evaluation
119 References
Appendix 16: Cyclohexanone
120 General description
120.1 Identity
120.2 Physical / chemical properties
121 Toxicokinetics
121.1 Human data
121.2 Animal data
121.3 Mode of action
122 Human toxicity
122.1 Single and repeated dose toxicity
122.1.1 Inhalation
122.1.2 Oral intake
122.1.3 Irritation
122.1.4 Sensitisation
122.2 Toxicity to reproduction
122.3 Mutagenic and genotoxic effects
122.4 Carcinogenic effects
123 Animal toxicity
123.1 Single dose toxicity
123.1.1 Inhalation
123.1.2 Oral intake
123.1.3 Dermal contact
123.1.4 Skin irritation
123.1.5 Eye irritation
123.1.6 Sensitisation
123.2 Repeated dose toxicity
123.2.1 Inhalation
123.2.2 Oral intake
123.2.3 Dermal contact
123.2.4 Other routes
123.3 Toxicity to reproduction
123.3.1 Inhalation
123.3.2 Oral intake
123.3.3 Dermal contact
123.4 Mutagenic and genotoxic effects
123.4.1 In vitro studies
123.4.2 In vivo studies
123.5 Carcinogenic effects
123.5.1 Inhalation
123.5.2 Oral intake
123.5.3 Dermal contact
124 Regulations
124.1 Ambient air
124.2 Drinking water
124.3 Soil
124.4 Occupational Exposure Limits
124.5 EU Classification
124.6 IARC
124.7 US-EPA
125 Summary
125.1 Description
125.2 Toxicokinetics
125.3 Human toxicity
125.4 Animal toxicity
125.4.1 Single dose toxicity
125.4.2 Repeated dose toxicity
125.4.3 Toxicity to reproduction
125.4.4 Mutagenic and genotoxic effects
125.4.5 Carcinogenic effects
126 Evaluation
127 References
Appendix 17: 1-Methylpyrrolidone (NMP)
128 General description
128.1 Identity
128.2 Physical / chemical properties
129 Toxicokinetics
129.1 Absorption and distribution
129.1.1 Inhalation
129.1.2 Oral intake
129.1.3 Dermal contact
129.1.4 Other routes
129.2 Elimination
129.2.1 Inhalation
129.2.2 Oral intake
129.2.3 Dermal contact
129.2.4 Other routes
129.3 Mode of action
130 Human toxicity
130.1 Single dose toxicity
130.2 Repeated dose toxicity
130.2.1 Inhalation
130.2.2 Oral intake
130.2.3 Dermal contact
130.3 Toxicity to reproduction
130.4 Mutagenic and genotoxic effects
130.5 Carcinogenic effects
131 Animal toxicity
131.1 Single dose toxicity
131.1.1 Inhalation
131.1.2 Oral intake
131.1.3 Dermal contact
131.1.4 Other routes
131.2 Repeated dose toxicity
131.2.1 Inhalation
131.2.2 Oral intake
131.2.3 Dermal contact
131.2.4 Other routes
131.3 Toxicity to reproduction
131.3.1 Inhalation
131.3.2 Oral intake
131.3.3 Dermal contact
131.3.4 Other routes
131.4 Mutagenic and genotoxic effects
131.4.1 In vitro studies
131.4.2 In vivo studies
131.5 Carcinogenic effects
132 Regulations
132.1 Ambient air
132.2 Drinking water
132.3 Soil
132.4 Occupational Exposure Limits
132.5 Classification
132.6 IARC
132.7 US-EPA
133 Summary
133.1 Description
133.2 Toxicokinetics
133.3 Human toxicity
133.3.1 Single dose toxicity
133.3.2 Repeated dose toxicity
133.3.3 Toxicity to reproduction
133.3.4 Mutagenic and genotoxic effects
133.3.5 Carcinogenic effects
133.4 Animal toxicity
133.4.1 Single dose toxicity
133.4.2 Repeated dose toxicity
133.4.3 Toxicity to reproduction
133.4.4 Mutagenic and genotoxic effects
133.4.5 Carcinogenic effects
134 Evaluation
135 References
Appendix 18: 1-Hydroxy-4-methyl-2-pentanone (HMP)
136 General description
136.1 Identity
136.2 Physico / chemical properties
137 Toxicokinetics
137.1 Absorption, distribution, metabolism and elimination
137.2 Mode of action
138 Human toxicity
138.1 Single and repeated dose toxicity
138.2 Toxicity to reproduction
138.3 Mutagenic and genotoxic effects
138.4 Carcinogenic effects
139 Animal toxicity
139.1 Single dose toxicity
139.1.1 Inhalation
139.1.2 Oral intake
139.1.3 Dermal contact
139.1.4 Irritation
139.1.5 Sensitisation
139.2 Repeated dose toxicity
139.2.1 Inhalation
139.2.2 Oral intake
139.2.3 Dermal contact
139.3 Toxicity to reproduction
139.4 Mutagenic and genotoxic effects
139.4.1 In vitro studies
139.4.2 In vivo studies
139.5 Carcinogenic effects
140 Regulations
140.1 Ambient air
140.2 Drinking water
140.3 Soil
140.4 Occupational Exposure Limits
140.5 EU-Classification
140.6 IARC
140.7 US-EPA
141 Summary
141.1 Description
141.2 Toxicokinetics
141.3 Human toxicity
141.4 Animal toxicity
141.4.1 Single dose toxicity
141.4.2 Repeated dose toxicity
141.4.3 Toxicity to reproduction
141.4.4 Mutagenic and genotoxic effects
141.4.5 Carcinogenic effects
142 Evaluation
143 References
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