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Appendices 1-18 to: Report on the Health Effects of Selected Pesticide Coformulants

57     Toxicokinetics

Only one study was found on calciumdodecylbenzenesulfonate (CaDBS).

2.1       Absorption, distribution, metabolism and elimination 

After oral administration to Wistar rats of 2 mg radiolabelled CaDBS, the radiolabel was detected in plasma after 15 minutes, reaching the maximum of 0.8 mg/g CaDBS at 2 hours, and then decreasing with time, the mean biological half-live being calculated to 10.9 hours.

Four hours after administration, the concentration of the radiolabel was high in the digestive tract, large intestine and in the urinary bladder (22.56, 43.24 and 34.89 mg/g salt, respectively). Concentrations were also high in the liver, kidney, testis, spleen and lung.

At 168 hours after administration, 51 % of the radioactivity was excreted in faeces and 50 % in urine. The 2 metabolites in urine and 2 of the 4 faecal metabolites were identified by thin layer chromatography to probably be sulfophenyl butanoic and sulfophenyl pentanoic acids. (Sunakawa et al. 1979 – quoted from WHO 1996).

The urinary metabolites point at CaDBS being degraded by w-oxidation followed by b-oxidation of LAS (Michael 1968 – quoted from WHO 1996).

57.1     Mode of action

No data on CaDBS were found in the literature.

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