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Appendices 1-18 to: Report on the Health Effects of Selected Pesticide Coformulants

61     Summary

Information on calciumdodecylbenzenesulfonate (CaDBS) is very scarce. Only one metabolism study and one report of acute oral toxicity in rats and mice were found in the literature.

61.1     Description

Calciumdodecylbenzenesulfonate is a yellowish liquid with a solvent odour or a white granular solid.

61.2     Toxicokinetics

CaDBS is readily absorbed from the gastrointestinal tract. No accumulation is seen in any organ. CaDBS is excreted equally via urine and faeces. From thin layer chromatography, the two urinary and two of the four faecal metabolites were identified to probably be sulfophenylbutanoic acid and sulfophenylpentanoic acid. The urinary metabolites point at CaDBS being degraded by w-oxidation followed by b-oxidation of linear alkylbezene sulfonate, LAS.

61.3     Human toxicity

No data were available on CaDBS.

61.4     Animal toxicity

Low acute oral toxicity is reported from rats and mice with LD₅₀ – values of 4000 mg/kg in rats and 3680 mg/kg in mice.

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