Preface

The Advisory list for self-classification of dangerous substances

The current report is a background report for the Danish EPA advisory self-classification list. The list is based on assessments from (Q)SAR researchers from the National Food Institute – Technical University of Denmark. The advisory self-classification list is available as a database via www.mst.dk.

This is a consolidated report, which includes documentation on all endpoints presently covered by the Danish EPA advisory self-classification list;

CMR and danger to the aquatic environment (from 2009) /62/
acute toxicity by oral intake (new 2010 update of 2001 endpoint)
skin irritation (new 2010 endpoint)
skin sensitisation from 2001 (not updated) /5/

This report provides the following background material:

Chapter 1: A general regulatory background on hazard classification of chemicals and how (Q)SAR based assessments can be used in this context.
Chapter 2: Description of the general methodology applied to make the advisory self-classifications.
Chapter 3: Description of the (Q)SAR models and the (Q)SAR based assessments in relation to the individual hazard classification criteria.
Chapter 4: Discussion and conclusions regarding comparisons of the current advisory self-classification list with the 2001 version of the list.