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The Advisory list for self-classification of dangerous substances

Contents

Preface

Summary

Dansk sammenfatning

1 Introduction to classification and (Q)SAR

• 1.1 Background
• 1.2 Classification of chemicals
• 1.3 (Q)SARs and their use in chemical assessment

2 Creation and use of the advisory self-classification list

• 2.1 The selected dangerous properties
• 2.2 The evaluated chemical substances
• 2.3 Test data
• 2.4 Reliability of (Q)SAR-predictions
• 2.5 Validation
• 2.6 Applicability domain
• 2.7 Application of the models
• 2.8 The result
• 2.9 How the self-classification list can help manufacturers and importers to comply with the classification duties

Technical description of the self-classifications

• 2.10 Mutagenicity
• 2.11 Carcinogenicity
• 2.12 Reproductive toxicity
• 2.13 Acute oral toxicity
  • 2.13.1 (Q)SAR based evaluation
• 2.14 Sensitisation by skin contact
  • 2.14.1 (Q)SAR based evaluation
• 2.15 Skin irritation
  • 2.15.1 (Q)SAR based evaluation
• 2.16 Danger to the aquatic environment

3 Discussion & Conclusions

• 3.1 Chemicals on AL2010 that were not on AL2001
• 3.2 Chemicals on AL2001 that are not on the current list
• 3.3 Conclusion

4 References

Annex 1. Glossary

Annex 2. Analysis of positive predictions of cancer classification

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Version 1.0 March 2010, © Danish Environmental Protection Agency