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Identification and assessment of alternatives to selected phthalates

Table 0.4 Overview of main toxicological and ecotoxicological properties
Name of substance CAS No. Health Environment Data quality /
data completeness
(CMR and PBT)
Acute, local and sens. effects (A/L/S) Carcinogenic (C) Mutagenic (M) Repro-toxic (R) Subchronic toxicity Persistence Bioaccumulation Aquatic Toxicity
*1 *2 *3 *4
ASE 91082-17-6 ○/○/○ - ○ ○ ● ●
(not readily)		 ●
Pow		 ○ 2 / 2
ATBC 77-90-7 ○/(○)/○ ○
 ○ ○ [●] ○ ●
BCF		 ● 1 / 2
COMGHA 330198-91-9 ○/○/○ - ○ - (●) ○ ●
Pow		 ● 1 / 2
DEGD 120-55-8 ○/(○)/○ - ○ (●) ● ○ (○)
BCF		 ● 1 / 2
DGD 27138-31-4 ○/(○)/○ - ○ (●) ● ○ ●
Pow		 ● 1 / 2
DEHT / DOPT 6422-86-2 ○/(○)/○ ○
 ○ ○ ● ●
(inherently)		 ●
Pow		 (●) 1 / 2
DINA 33703-08-1 ○/○/○ - ○
 - ● ○ (●)
(conflicting)		 ○ 1 / 2
DINCH 166412-78-8 ○/(○)/○ ○
 ○ ○ ● ●
(not readily)		 ●
Pow		 ○ 1 / 2
GTA 102-76-1 ○/○/○ - ○ ○ ○ ○ ○ ○ 1 / 2
TXIB 6846-50-0 ○/(○)/○ - ○ ● ● ●
(inherently)		 ○
BCF		 ● 1 / 2

Notes:

The inherent properties for the investigated substances are summarised using key parameters: acute and local effects, sensitisation, carcinogenicity(C), mutagenic toxicity (M), reproductive toxicity (R), persistence, bioaccumulation and aquatic toxicity. If data are not available for all parameters or only from non standard test results a tentative assessment is given (shown in parentheses). The symbols: ● identified potential hazard, ○ no identified potential hazard, and – no data available. [] indicate the effects are considered of minor significance.

*1 The terms refer to different biodegradability tests:

Inherently biodegradable: Not meeting the criteria in an "inherent biodegradability" test

Not readily biodegradable: Not meeting the criteria in "ready biodegradability" tests.

*2 ● is based on BCF > 100 or Pow > 3 (BCF prevails over Pow where both values exist).

*3 ●● is used for very toxic and toxic < 10 mg/L.

*4 The following notation is used:

Data quality (first number):

  1. Data summaries from recognised, peer reviewed sources (e.g. EU HVP programme, SIDS, SCHENIR, NICNAS) or reliable test data.
  2. Data summaries from not peer reviewed sources, considered reliable with restrictions (e.g. IUCLID).
  3. Data summaries which do not give sufficient experimental details for the evaluation of
    the quality.

Data completeness (second number):

  1. Data considered sufficient for classification of CMR effects and according to PBT criteria.
  2. Data available about the endpoint, but not considered sufficient for classification.
  3. Data not available or relevant for classification of the endpoint.

An average score is assigned based on the sum of scores for C, M, R, P, B and T properties as follows: Sum 6-8=1, Sum 9-14=2 and Sum 14-18=3

 

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Version 1.0 November 2010, © Danish Environmental Protection Agency