| ASE |
91082-17-6 |
O: 26,380-31,650 mg/kg
D: > 1,055 mg/kg
I: ND |
Skin: No irritation
Eye: No irritation |
NOAEL, 90 days:
228 mg/kg/day (m)
282.6 mg/kg/day (f)
(increased kidney weight)
|
ND |
Negative
(Ames, mammalian cells)
Reliable guideline studies for in vitro mammalian mutagenicity/genotoxicity. No in vivo studies available. |
No reliable data. |
- |
| ATBC |
77-90-7 |
O: > 30 g/kg
D: ND
I: ND |
Skin: No or slight irritation
Eye: No or slight irritation
Not sensitising |
NOAEL, 90 days:
300 mg/kg/day
(increased kidney weight)
NOAEL, 2 years:
100 mg/kg/day
(conservative)
NOAEL, 13 weeks:
100 mg/kg/day (m)
300 mg/kg/day (f)
(reduced body weight gain, increased liver weights, hepatic hypertrophy) |
(No carcinogenicity observed in 2 year oral repeated dose toxicity study)
No guideline study available. Existing study reliable with restrictions (lack of detail). |
Negative
(Ames, mammalian cells, in vivo/in vitro UDS test)
Reliable (with some restrictions) guideline studies for in vitro mammalian mutagenicity/genotoxicity. No in vivo studies available. |
Not considered toxic to reproduction (2-generation study)
NOAEL: 100 mg/kg/day (parental, offspring)
Reliable data available for both reproductive and developmental toxicity. Data for developmental toxicity lack some details. |
Weak signs of neurotoxicity |
| COMGHA |
330198-91-9 |
D: > 2,000 mg/kg |
Skin: No irritation
Eye: No irritation
Not sensitising |
NOAEL, 90 days: < 3 ml/kg/day |
ND |
Negative
(Ames, chromosomal aberration test)
Reliable guideline studies for in vitro mammalian mutagenicity/genotoxicity. No in vivo studies available. |
ND |
- |
| DEGD |
120-55-8 |
O: 4,198 mg/kg
D: > 2,000 mg/kg
I: > 200 mg/L |
Skin: No irritation
Eye: Slight irritation
Not sensitising |
NOAEL, 13 week:
1,000 mg/kg/day
(reduced body weight gain, haemosiderosis in spleen, hepatocyte hypertrophy) |
ND |
Negative
(Ames, mammalian cells, chromosomal aberration test)
Reliable guideline studies for in vitro mammalian mutagenicity/genotoxicity. No in vivo studies available. |
Developmental tox:
NOEL: 1,000 mg/kg/day
(maternal)
NOAEL: 500 mg/kg bw/day
(prenatal dev.)
NOEL: 250 mg/kg bw/day
(foetal growth)
Reproductive tox.:
NOAEL: 10,000 ppm (500 mg/kg bw/day)
(F0 and F1 parents)
NOAEL: 3,300 ppm (165 mg/kg bw/day)
(offspring)
NOEL: 10,000 ppm (500 mg/kg bw/day)
(reproductive)
Reliable guideline studies with GLP for both developmental and reproductive toxicity.. |
No estrogenic activity up to 2,000 mg/kg/day (Endpoints: vaginal cornification and uterotrophic response) |
| DGD |
27138-31-4 |
O: 3,914 mg/kg
D: > 2,000 mg/kg
I: > 200 mg/L (4h) |
Skin: No irritation
Eye: Slight irritation
Not sensitising |
NOAEL, 13 week:
1,000 mg/kg/day
(reduced body weight gain, haemosiderosis in spleen, hepatic hypertrophy) |
ND |
Negative
(Ames, mammalian cells, chromosomal aberration test)
Reliable guideline studies for in vitro mammalian mutagenicity/genotoxicity. No in vivo studies available. |
Developmental tox:
NOEL: 1,000 mg/kg/day
(maternal)
NOAEL: 500 mg/kg/day
(prenatal dev.)
NOEL: 250 mg/kg/day
(foetal growth)
Reproductive tox.:
NOAEL: 10,000 ppm
(F0 and F1 parents)
NOAEL: 10,000 ppm
(offspring)
Reliable guideline studies with GLP for both developmental and reproductive toxicity.. |
No estrogenic activity up to 2,000 mg/kg/day (Endpoints: vaginal cornification and uterotrophic response) |
| DEHT / DOPT |
6422-86-2 |
O: > 5,000 mg/kg
D: > 19,670 mg/kg
(guinea pig)
I: no deaths in mice exposed to saturated vapour (4h) |
Skin: Slight irritation
Eye: Slight irritation
Not sensitising |
NOAEL, 90 days, 21 days
500 mg/kg/day
(increased relative liver weight)
NOEL, 104 weeks, 1500 ppm (79 mg/kg/day (m) and 102 mg/kg/day (f)) |
2-year study: No signs of tumorigenicity (unreviwed study, few details)
104 week: NOEL: ³12000 ppm (666 mg/kg bw/day (m) and 901 mg/kg bw/day (f)) - highest dose tested (industry data)
No data on guidelines for the studies. The industry study appears to follow established guidelines. |
Negative
(Ames, chromosomal aberration test)
Reliable studies for in vitro mammalian mutagenicity/genotoxicity. No in vivo studies available. |
Developmental tox:
NOEL: 458 mg/kg/day
(maternal)
NOEL: 747 mg/kg/day
(developmental)
Reproductive tox.:
NOAEL: 500 - 700 mg/kg/day (m)
800 - 1,000 mg/kg/day (f)
NOAEL, tox:
150 - 200 mg/kg/day (m)
250 - 300 mg/kg/day (f) (parental, offspring)
Reliable guideline studies with GLP for both developmental and reproductive toxicity.. |
No estrogenic activity (Uterotrophic assay) |
| DINA |
33703-08-1 |
O: > 5,000 mg/kg
D: > 3,160 mg/kg |
Skin: No irritation
Eye: No irritation
Not sensitising |
NOAEL, 13 week (dog):
274 mg/kg/day
(reduced body weight gain, increased liver weight, elevated enzyme levels, liver and kidney histopathology) |
ND |
Negative
(Ames, mammalian cells)
Reliable studies for in vitro mammalian mutagenicity/genotoxicity. No in vivo studies available. |
No data |
- |
| DINCH |
166412-78-8 |
O: > 5,000 mg/kg
D: > 2,000 mg/kg |
Skin: Slight irritation
Eye: No irritation
Not sensitising |
NOAEL, 28 days:
318 mg/kg/day (m)
342 mg/kg/day (f)
(liver and kidney clinical chemistry)
NOAEL, 90 days:
107.1 mg/kg/day (m)
389.4 mg/kg/day (f)
(kidney weight changes, degenerated epithelial cells in urine (m))
NOAEL, 12 months:
40 mg/kg bw/day (m) and 200 mg/kg bw/day (f) - l(iver and kidney weight (m) changes) |
No findings of relevance for carcinogenicity in humans in combined chronic tox. and carc. test.
Reliable guideline study. |
Negative
(Ames, signs of chromosomal aberration - but considered non-genotoxic). Not found to be clastogenic or aeuploidogenic in micronucleus test.
Reliable guideline studies for in vitro mammalian mutagenicity/genotoxicity and in vivo mammalian micronucleus test. |
No developmental toxicity at doses up to 1,000 mg/kg/day
Not considered toxic to reproduction (2-generation study up to 1,000 mg/kg/day)
NOAEL, tox.: 100 mg/kg/day (F1)
Reliable guideline/combined guideline studies for both developmental (rat and rabbit) and reproductive (rat) toxicity. in |
- |
| GTA |
102-76-1 |
O: > 2,000 mg/kg
D: > 2,000 mg/kg
I: > 1,721 mg/m³ |
Skin: No irritation
Eye: No irritation
Not sensitising |
Combined repeat dose /dev. screening:
No effects at tested doses up to 1,000 mg/kg/day
90 days, inhalation: No signs of toxicity up to 2,220 mg/m³ |
ND |
Negative
(Ames, mammalian cells, chromosomal aberration test, in vivo mouse nucleus)
Reliable guideline studies for in vitro mammalian mutagenicity/genotoxicity and in vivo mammalian micronucleus test. |
Combined repeat dose / dev. screening: No significant adverse effect on reproductive parameters or offspring
NOAEL(Dev/Repr.): 1000 mg/kg bw/day.
Reliable guideline study. |
- |
| TXIB |
6846-50-0 |
O: > 3,200 mg/kg
D: > 2,000 mg/kg
I: > 5.3 mg/L (6h) |
Skin: Slight irritation (guineas pigs)
no irritation (rats and humans)
Eye: No irritation
Not sensitising |
NOAEL, 103 days, rat:
0.1% in diet
(slight increase in relative and absolute liver weight) |
ND |
Negative
(Ames, mammalian cells)
Reliable guideline studies for in vitro mammalian mutagenicity/genotoxicity. No in vivo studies available. |
Combined repeat dose / dev. screening:
NOEL,parental and F1: 750 mg/kg/day
No effects on reproduction
Combined study:
NOAEL: repr., dev.:
276 mg/kg/day (m)
359 mg/kg/day (f)
Reliable guideline studies for both developmental and reproductive toxicity.. |
- |