2 Creation and use of the CLP-version of the advisory self-classification list

The Advisory list for self-classification of dangerous substances

2.1 The selected dangerous properties

The current chapter describes how the CLP-version of the advisory list was prepared. Since much of the new list is based on the previous list, reference is made to the previous report /11/ in relation to a number of issues:

The evaluated chemical substances
Use of test data
(Q)SAR reliability and validation

2.1 The selected dangerous properties

The table below provides an overview of the dangerous properties and classifications of the substances investigated the advisory list.

Dangerous property	Classification	Wording of CLP-classification	Change of self-classification criteria
Mutagenicity	Muta2	Suspected of causing genetic defects	No
Carcinogenicity	Carc2	Suspected of causing cancer	No
Reproductive toxicity	Repr2	Suspected of damaging fertility or the unborn child	No
Acute oral toxicity	AcuteTox1	Fatal if swallowed	yes
	AcuteTox2	Fatal if swallowed
	AcuteTox3	Toxic if swallowed
	AcuteTox4	Harmful if swallowed
Sensitisation by skin contact	SkinSens1	May cause an allergic skin reaction	No
Irritant	SkinIrr2	Causes skin irritation	Yes*
Danger to the aquatic environment	Acute1	Very toxic to aquatic life	yes
	Chronic1	Very toxic to aquatic life with long lasting effects
	Chronic2	Toxic to aquatic life with long lasting effects
	Chronic3	Harmful to aquatic life with long lasting effects

Table 1: Advisory classifications in the CLP-version of the advisory list

*: Even though the classification criteria was slightly changed, the employed (Q)SAR approach remained unchanged (c.f. the text).