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Effects of azole fungicides on the function of sex and thyroid hormones

Figure 4 - Anti-estrogenic effects of the four fungicides: epoxiconazole, prochloraz, propiconazole, and tebuconazole tested in the MCF-7 cell proliferation assay. All four fungicides inhibited the proliferation of MCF-7 cells induced by 10 pM 17β-estradiol. Data represent mean±SD for three to seven independent experiments. The horizontal gray line represents the control level and the dashed gray lines represent the SD of the control. * Statistically significantly different from control (10 pM 17β-estradiol) (p<0.05). c = tested cytotoxic by use of a LDH-test. RPE = Relative Proliferative Effect.

Figure 4 - Anti-estrogenic effects of the four fungicides: epoxiconazole, prochloraz, propiconazole, and tebuconazole tested in the MCF-7 cell proliferation assay. All four fungicides inhibited the proliferation of MCF-7 cells induced by 10 pM 17β-estradiol. Data represent mean±SD for three to seven independent experiments. The horizontal gray line represents the control level and the dashed gray lines represent the SD of the control. * Statistically significantly different from control (10 pM 17β-estradiol) (p<0.05). c = tested cytotoxic by use of a LDH-test. RPE = Relative Proliferative Effect.

 

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Version 1.0 October 2007, © Danish Environmental Protection Agency