Pesticides Research No. 111 2007

Effects of azole fungicides on the function of sex and thyroid hormones

Abstract
Azole-fungicides are frequently used in Denmark. Epoxiconazole, propiconazole, and tebuconazole had endocrine disrupting properties in cell based assays. In rats, epoxiconazole and tebuconazole increased gestational length, maternal progesterone level, and masculinized female-offspring. Besides, tebuconazole caused feminization of male-offspring. Similar effects were previously demonstrated for prochloraz. The results indicate that azole-fungicides in general have endocrine disrupting properties.

Abstract in Danish

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Version 1.0 October 2007, © Danish Environmental Protection Agency