Pesticides Research No. 111 2007 – Effects of azole fungicides on the function of sex and thyroid hormones

Effects of azole fungicides on the function of sex and thyroid hormones

Colophon

Title:
Effects of azole fungicides on the function of sex and thyroid hormones

Key Subjects:
pesticides; effects

Key Subjects in Danish:
pesticider; hormonforstyrrende stoffer; effekter

Abstract:
Azole-fungicides are frequently used in Denmark. Epoxiconazole, propiconazole, and tebuconazole had endocrine disrupting properties in cell based assays. In rats, epoxiconazole and tebuconazole increased gestational length, maternal progesterone level, and masculinized female-offspring. Besides, tebuconazole caused feminization of male-offspring. Similar effects were previously demonstrated for prochloraz. The results indicate that azole-fungicides in general have endocrine disrupting properties.

Abstract in Danish:
Azol-fungicider er hyppigt anvendte svampemidler i Danmark. Epoxiconazol, propiconazol, og tebuconazol udviste hormonforstyrrende egenskaber i cellebaserede testsystemer. I rotter, øgede epoxiconazol og tebuconazol drægtighedslængden, forøgede progesteronniveauet hos moderdyrene samt maskuliniserede hun-ungerne. Tebuconazol medførte desuden en feminisering af han-unger. Lignende effekter er tidligere påvist for prochloraz. Resultaterne tyder på at azol-fungicider generelt har hormonforstyrrende egenskaber.

Series title and no.:
Pesticides Research No. 111 2007

Publisher:
Danish Environmental Protection Agency

Performing organizations:

1 University of Southern Denmark, Institute of Public Health, Research Unit of Environmental Medicine; 2 Technical University of Denmark, the National Food Institute, Department of Toxicology and Risk Assessment

Copyright:
Danish Environmental Protection Agency

Creators:
1 Mia Birkhøj Kjærstad and Helle Raun Andersen
2 Camilla Taxvig, Ulla Hass, Marta Axelstad, Stine Metzdorff and Anne Marie Vinggaard

Contributor:
Schultz Grafisk (web)

Language:
eng

URL:
http://www.mst.dk/

ISBN nr. Electronic version:
978-87-7052-538-1

Version:
1.0

Version/edition:
2007-10-25

Data formats:
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