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Effects of azole fungicides on the function of sex and thyroid hormones

Figure 6 - Effects on the enzyme aromatase of the four fungicides: epoxiconazole, prochloraz, propiconazole, and tebuconazole tested in the MCF-7 cell proliferation assay. All four fungicides inhibited the 1 µM testosterone (converted by aromatase to estrogen) induced MCF-7 cell proliferation. Data represent mean±SD for three independent experiments. The horizontal gray line represents the control level and the dashed gray lines represent the sd of the control. *Statistically significantly different from control (1 µM testosterone) (p<0.05). c = tested cytotoxic by a LDH-test. RPE = Relative Proliferative Effect.

Figure 6 - Effects on the enzyme aromatase of the four fungicides: epoxiconazole, prochloraz, propiconazole, and tebuconazole tested in the MCF-7 cell proliferation assay. All four fungicides inhibited the 1 µM testosterone (converted by aromatase to estrogen) induced MCF-7 cell proliferation. Data represent mean±SD for three independent experiments. The horizontal gray line represents the control level and the dashed gray lines represent the sd of the control. *Statistically significantly different from control (1 µM testosterone) (p<0.05). c = tested cytotoxic by a LDH-test. RPE = Relative Proliferative Effect.

 

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Version 1.0 October 2007, © Danish Environmental Protection Agency