Alternatives to animal experiments for eye irritation PrefaceThe Danish Environmental Protection Agency has sponsored the project "Validation of a three-dimensional model for eye and skin irritation". The study has been conducted as a joint venture between the Danish Environmental Protection Agency and the Danish Veterinary and Food Administration, Institute of Food Safety and Toxicology. The studies with the tissue model SKIN2 ZK1200 have been published in 4 articles that are the basis of the present report: Brantom, P. G. et al.: A summary report of the COLIPA international validation study on alternatives to the Draize rabbit eye irritation test. Toxicology in Vitro, 1997, 11, 141-179. Espersen, R. J., Olsen, P., Nicolaisen, G., Jensen, B. L. and Rasmussen, E. S.: Assessment of recovery from ocular irritancy using a human tissue equivalent model. Toxicology in Vitro, 1997, 11, 81-88. Rasmussen, E. S.: Use of reconstructed human tissue models in toxicological and pharmacological studies. Dansk Veterinærtidsskrift, 1/11, 1996, 943-948. Southee, J. A., McPherson, J. P., Osborne, R., Carr, G. J. and Rasmussen, E. S.: The performance of the tissue equivalent assay using the SKIN2TM ZK1200 model in the COLIPA international validation study on alternatives to the Draize eye irritation test. Toxicology in Vitro, 1999, 13, 355-373. The project has been followed by a steering group with the following members: The Danish Environmental Protection Agency: The Danish Veterinary and Food Administration: The project has been accomplished by a project group at the Institute of Food Safety and Toxicology with the following members: René Espersen The members of the steering group and the project gruop are acknowledged for their excellent collaboration. |
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