Alternatives to animal experiments for eye irritation.

Contents

Preface

Summary

1. Introduction

2. Reconstructed tissue models
2.1 Reconstruction of tissues

3. The COLIPA study
3.1 Design of the study
3.2 Alternative methods
3.3 Prediction models
3.4 Test substances
3.5 Distribution of test substances and collection of in vitro results
3.6 Statistical analyses
3.7 Further analyses of the results obtained in the COLIPA study.
3.8 Discussion

4. Test for recovery from ocular irritation
4.1 Method
4.2 Results
4.3 Discussion

5. Validation of alternatives to ocular irritancy tests

6. Evaluation of alternatives to ocular irritancy tests

7. Abbreviations

8. References