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In Vivo Investigation of Dietary Exposure to 5 Pesticides

Appendix C:
Haematology, organ weights, macroscopic and microscopic pathology of the combined exposure study

(Study No. 02-22)

Haematology

Table 1C. Group results males, mean and standard deviation (st.dev) for White blood cell count (WBC), red blood cell count (RBC), haemoglobin (hb), Haematocrit (Hct), Mean corpuscular volume (MCV), Mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) and platelets (Plt).

Table 1C
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*Significantly different from control (group 1), P<0.05

Table 2C. Differential count of white blood cells (%), lymphocytes (L), polymorphonuclear neu-trophils (N), monocytes (M) and polymorphonuclear eosinophils (E). Group results male, mean and standard deviation (st. dev.)

Table 2C
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Table 3C. Group results females, mean and standard deviation (st.dev) for White blood cell count (WBC), red blood cell count (RBC), haemoglobin (hb), Haematocrit (Hct), Mean corpuscular volume (MCV), Mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) and platelets (Plt).


Table 3C
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*Significantly different from control (group 1), P<0.05

Table 4C. Differential count of white blood cells (%), lymphocytes (L), polymorphonuclear neutrophils (N), monocytes (M) and polymorphonuclear eosinophils (E). Group results females, mean and standard deviation (st. dev.)

Table 4C
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Absolute and relative organ weights

Table 5C. Absolute organ weights (g) presented as mean and standard deviation, group results males

Table 5C
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*Significantly different from control (group 1), P<0.05.

Table 6C. Relative organ weights presented as (mean and standard deviation) x 100, group results males

Table 6C
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*Significantly different from control (group 1), P<0.05.

Table 7C. Absolute organ weights (g) presented as mean and standard deviation, group results females

Table 7C
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*Significantly different from control (group 1), P<0.05

Table 8C. Relative organ weights presented as (mean and standard deviation) x 100, group results females

Table 8C
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*Significantly different from control (group 1), P<0.05. (*) not significant by dunnetts

Histopathology

Table 9C. Microscopic findings in control (group 1) and highest dose group (group 6). N: Normal R: remarks (see list below).

Table 9C
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N: Normal R: Remarks see below

Remarks:

Oesophagus:

Group 1, male No 6: Tissue missing

Group 6, male No 164, female No 181, 182, 183: Tissue missing

Stomach:

Group 6, male no 164: Tissue missing

Jejunum:

Group 1, male No 6, 7 and female No. 17,18: One lymphoid follicle (peyer patch) present in lamina propria.

Group 6, female No. 182: One lymphoid follicle (peyer patch) present in lamina propria.

Colon:

Group 6, female No 177: 4 lymphoid nodules in lamina propria.

Rectum:

Group 6, male No 165: Tissue missing

Group 6, female No. 183: One lymphoid follicle in tela submucosa.

Trachea:

Group 1, female No. 21: Focus of lymphocyte infiltration under the epithelium Group 6, female No. 182, 183: Tissue missing

Kidneys:

Group 1, female No 23: Pelvic inflammation grade 1 Group 6, male No165: Tubular cell regeneration

Liver:

Group 1 male No. 1, 2, 3, 5, 6, 7, 8: 1-3 foci of inflammatory cells Group 6 male 161-168: Mild degree of centrilobular cell hypertrophia Male No. 161, 162, 163, 165, 167, 168: 1-3 foci of inflammatory cells Group 1 female No. 17, 19, 20, 21: 1-2 foci of inflammatory cells Group 6 female No. 182, 183, 184: Mild degree of centrilobular cell hyper-trophia Female No. 177, 179, 181, 182, 183: 1-3 foci of inflammatory cells

Adrenal glands:

Group 1, female No. 17: Medulla missing in two sections

Thyroid gland:

Group 1, female No.24: Mild degree of follicular cell hypertrophy

Group 6, male No.161, 162, 163, 165, 166, 167, 168: Mild degree of follicular cell hypertrophy Group 6, female No. 177, 178, 179, 180, 183, 184: Mild degree of follicular cell hypertrophy

Thymus:

Group 1 male No 2: Number of macrophages in cortex increased

Group 6 male No 164, 168: Number of macrophages in cortex increased

Lnn. Axillaris:

Group 1, male No. 8, female No 23: Tissue missing

Epidymidis:

Group 6, male No. 162: Decreased amount of sperm in both caput and cauda of right epidymidis male No. 168: Vacuolarization of epithelium of Right epidymidis

Prostate gland:

Group 6, male No165: Inflammation in lateral prostate

Male No. 166: Tissue missing

Vagina:

Group 1, female No. 17, 20: Tissue missing Group 6, female No. 179: Tissue missing

Sciatic nerve:

Group 1, female No 17, 23: Tissue missing Group 6, male No. 165: Tissue missing Group 6, female No. 178: Tissue missing

Spinal cord:

Group 1, male No. 6: Tissue of cervical region missing Group 6, male No. 165: Tissue missing Group 6, female No. 181: Tissue missing No 180: Tissue of thoracal region missing No 184: Tissue of lumbar region missing

Bone marrow:

Group 6, male No. 165: Tissue missing Group 6, female No. 181: Tissue missing

 

 

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