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Toxicological Evaluation and Limit Values for Nonylphenol, Nonylphenol Ethoxylates, Tricresyl, Phosphates and Benzoic Acid

Table of contents

Preface

Principles for setting of limit values for chemical substances

Nonylphenol and nonylphenol ethoxylates

1. General description
1.1 Identity
1.2 Physical/chemical properties
1.3 Production and use
1.4 Environmental occurrence
1.5 Environmental fate
1.6 Human exposure

2. Toxicokinetics
2.1 Absorption, distribution
2.2 Elimination
2.3 Toxicological mechanisms

3. Human toxicity
3.1 Short term toxicity
3.2 Long term toxicity
3.3 Reproductive / Developmental effects
3.4 Genotoxic effects
3.5 Carcinogenic effects

4. Toxicity, animal data
4.1 Short term toxicity
4.2 Long term toxicity
4.3 Reproductive / developmental effects
4.4 Genotoxic effects
4.5 Carcinogenic effects

5. Regulations, limit values

6. Summary

7. Evaluation

8. TDI, health based limit values
8.1 TDI
8.2 Limit value in soil
8.3 Limit value in drinking water
8.4 Limit value in air

9. C-value
9.1 Quality criteria in soil
9.2 Quality criteria in drinking water
9.3 C-value

10. References

Tricresyl phosphates

1. General description
1.1 Identity
1.2 Physical/chemical properties
1.3 Production and use
1.4 Environmental occurrence
1.5 Environmental fate
1.6 Human exposure

2. Toxicokinetics
2.1 Absorption, distribution
2.2 Elimination
2.3 Toxicological mechanisms

3. Human toxicity
3.1 Short term toxicity
3.2 Long term toxicity
3.3 Reproductive and Developmental effects
3.4 Mutagenic and genotoxic effects
3.5 Carcinogenic effects

4. Toxicity, animal data
4.1 Short term toxicity
4.1.1 Studies on all possible TCP isomers
4.1.2 Studies on o-TCP
4.1.3 Studies on other TCP´s
4.1.4 Study on o-TCP
4.2 Long term toxicity
4.2.1 o-TCP
4.2.2 Other TCP´s
4.2.3 o-TCP
4.3 Reproductive and developmental effects
4.3.1 o-TCP
4.3.2 Other TCP´s
4.4 Mutagenic and genotoxic effects
4.5 Carcinogenic effects

5. Regulations, limit values

6. Summary

7. Evaluation
7.1.1 o-TCP
7.1.2 TCP´s containing less than 0,1% o-TCP

8. TDI, health based limit values
8.1 TDI
8.2 Limit value in soil
8.3 Limit value in drinking water

9. C-value
9.1 Quality criteria in soil
9.2 Quality criteria in drinking water

10. References

Benzoic acid

1. General description
1.1 Identity
1.2 Physical/chemical properties
1.3 Production and use
1.4 Environmental occurrence
1.5 Environmental fate
1.6 Human exposure

2. Toxicokinetics
2.1 Absorption, distribution
2.2 Elimination
2.3 Toxicological mechanisms

3. Human toxicity
3.1 Short term toxicity
3.2 Long term toxicity
3.3 Reproductive / Developmental effects
3.4 Genotoxic effects
3.5 Carcinogenic effects

4. Toxicity, animal data
4.1 Short term toxicity
4.2 Long term toxicity
4.3 Reproductive and developmental effects
4.4 Mutagenic and genotoxic effects
4.5 Carcinogenic effects

5. Regulations, limit values

6. Summary

7. Evaluation

8. TDI, health based limit values

9. C-value

10. References

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